The lifetime of genetically pre-programmed superhealth Nor do they deliver the rapturous but addictive rush of a fast-acting euphoriant.Ĭontemporary therapeutic mood-boosters yield desperately little joy compared to With tomorrow's revolutionary designer-drugs. Present-day mood-brighteners, whether herbal But its efficacy in treating cocaine-induced depression is untested Medicine is not a dependable remedy for deep melancholicĪntidepressant. (St John's wort), may be taken indefinitely. If the user wishes to Say No To Drugs completely, then a "natural", gentle mood-brightener Inhibitor and/or anti-anxiety agents e.g. (Effexor), milnacipran (Ixel) or duloxetine (Cymbalta),ĭual-action serotonin and noradrenaline reuptake inhibitors perhaps a glutamate-enhancing agent such as modafinil ( Provigil) or more daringly,Īmineptine ( Survector), a dopamine reuptake (Norpramin), a noradrenaline reuptake inhibitor venlafaxine So in place of cocaine, the option of taking one or more clinically In effect, such users are self-medicating, even if they ostensibly Pre-existing psychiatric disorder - even by the touchstone of today's impoverished Hard work and clean living isn't always the recipe for a happy life either. Unfortunately, opting to embrace godliness, This course of action may indeed be prudent given our bug-ridden genome and currentĬrop of misbegotten street drugs. No." The ex-addict is encouraged to renounce "unnatural" chemical highs altogether. Some drug-pundits recommend Total Abstinence from chemical assistance: "Just Say JHW007 has a high affinity for the dopamine transporter with minimal cocaine-like subjective and behavioural effects. It serves as a functional antagonist to cocaine. Much more research will be needed before it ever gets a product license.Īnother future option may be the benztropine analog JHW007. PAL-287 is a rationally-designed drug aimed at treating stimulant dependence while having minimal "abuse potential" of its own. In future, designer BChE may offer an effective therapy to reverse cocaine overdoses and combat cocaine addiction.Īnother future option for cocaine addicts who want to quit may be taking a dual dopamine/serotonin releaser. Reported a mutant form of the BChE plasma enzyme that broke down cocaine some 2,000 times faster than the natural blood protein. In September 2008, scientists from the University of Kentucky
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The primary cocaine-metabolising enzyme in the body is butyrylcholinesterase (BChE). Use sometimes causes colour vision defects the most common adverse side-effects Feedback inhibition between the "feel good"ĭopaminergic and GABA-ergic neurotransmitter systems explains vigabatrin's therapeutic GABA-T the enzyme responsibleįor the catabolism of the inhibitory neurotransmitter gamma-aminobutyric acid
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Of gamma-aminobutyric acid transaminase (GABA-T). (Sabril), though it isn't licensed in the USA. The possible coercive use of "vaccines against pleasure" raises profound ethicalĪddicts motivated to quit might consider a course of the antiepileptic drug vigabatrin Perhaps children "at risk" will be vaccinated at an early age. In theory, cocaine-specific antibodies which sequester the drug before its passage into the brain will prevent the relapsing user getting high. They are designed to induce drug-specificĪntibodies in the bloodstream. Another option is joining Cocaine Anonymous. Is useful as well [and probably Faith In Jesus, though this isn't always a realistic Indeed this cue-elicited craving may even increase during the first few months of withdrawal.įood, particularly an idealised stone-age diet
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Major cause of relapse in recovering coke-users. Often without undue difficulty, because most of the "conditioned cues and reinforcers"Īssociated with narcotic drug-use in South-East Asia were missing back home.Įspecially a holiday in the company of supportive family and (drug-free) friends,Ĭan help break a user's self-destructive cycle of coke-binges. In Vietnam kicked the habit when they returned to the USA.
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Most of the GIs who got hooked on unmistakably physically addictive heroin Is a crackhead inescapably doomed to an early grave? Or are there ways (s)he can The price of pleasure almost as severely as the addict. Tragically, the user's family and loved ones may suffer For there is nothing in life that's naturally If one succumbs to curiosity, and finds out what one is missing, then the rest at least until one's death-bed - because its euphoric effect is so extraordinarily hard to forget. So it's reckless to try crack cocaine at all Its mechanisms don't subvert the systems of homeostaticįeedback inhibition of the brain. Such immense well-being is unsustainable because
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A once-in-a-lifetime experience? HOW TO QUIT COCAINEThe high from crack cocaine is intensely rewarding.īut the experience is short-lived.